Endoscopic Ultrasound guided perivascular pancreatic Radiofrequency Ablation using a Hydroxyethyl Starch Solution prior to Pancreatectomy

Background and study aim. Pancreatic surgery remains complex, particularly for borderline resectable locally advanced tumours. Vascular invasion compromises resectability, vascular resection entails increased morbidity mortality. Following a feasibility safety demonstration of an augmented endoscopic ultrasound (EUS) guided radiofrequency ablation (RFA) using hydroxyethyl starch (HES) in porcine pancreatic parenchyma, the present assesses whether this approach (EUS-sugar-RFA) perivascular space is safe creates controllable margin necrosis to enable vessel-sparing resection. Methods. EUS-sugar-RFA parenchyma adjacent splenic artery vein was performed live animal model. different survival periods (0-4 days) interventional group (n=3), open pancreatectomy carried out. The control (n=4) included pancreatectomies two pigs with non-treated pancreases RFA alone on same day. Results. All procedures were completed successfully, without intra- or postoperative complications. Survival uncomplicated. Histopathological examination showed local inflammatory reaction at sites. wall integrity preserved all specimens. untreated zones no from normal group. Conclusions. Preoperative HES safe, model best timeframe within 24h prior surgery. This technique might improve resectability selected cancers.